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For prescriptions where a measuring product will not be supplied, a pharmacist can provide an appropriate calibrated measuring machine and can provide Recommendations for measuring the proper dose.
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Due to threat of respiratory depression, keep away from the use of opioid antitussives, which include Promethazine HCl and Codeine Phosphate Oral Remedy in individuals with compromised respiratory purpose, people liable to respiratory failure, and in aged, cachectic, or debilitated sufferers.
Young children could be far more sensitive towards the Unwanted side effects of the drug, Particularly slowed respiration and uncontrolled movements (see also Warning part). Kids might also experience excitability as opposed to drowsiness.
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Read the Medication Guide furnished by your pharmacist Before you begin having promethazine/phenylephrine/codeine and every time you obtain a refill. For those who have any concerns, request your health practitioner or pharmacist.
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This could certainly take place Even though you consider Promethazine Hydrochloride and Codeine Phosphate Oral Answer accurately as prescribed by your healthcare service provider. Your threat of habit, abuse, and misuse is enhanced should you or possibly a loved one provides a history of drug or Alcoholic beverages abuse or dependancy, or psychological medical problems.
Codeine Carcinogenicity scientific studies ended up executed with codeine. Two-calendar year scientific tests in F344/N rats and B6C3F1 mice had been carried out to evaluate the carcinogenic probable of codeine. No evidence of tumorigenicity was observed in male and female rats at codeine dietary doses approximately 70 and eighty mg/kg/day (approximately such as 15 and 20 occasions, the MRHD on a mg/m2 foundation, respectively).
Propulsive peristaltic waves inside the colon are lessened, although tone may be enhanced to The purpose of spasm causing constipation. Other opioid-induced effects may well include things like a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Tend not to flush medicines down the bathroom or pour them right into a drain Except instructed to take action. Correctly discard this products when it is expired or now not essential. Speak to your pharmacist or neighborhood squander disposal firm.
Printed scientific tests with codeine have noted inconsistent results and also have crucial methodological restrictions (see Facts). There are actually experiences of respiratory depression when codeine is applied for the duration of labor and shipping (see Scientific Things to consider).
Concomitant administration of promethazine solutions with other respiratory depressants has an Affiliation with respiratory melancholy, and sometimes Demise, in pediatric Promethazine codeine syrup clients.